一、产品名称

人生就是博-尊龙凯时的Anti-CD19(FMC63)，CD19抗体，CAR特异性抗体蛋白

Anti-CD19(FMC63)CAR特异性抗体-尊龙凯时人生就是博

二、产品描述

FMC63抗体是一种针对人CD19的鼠单克隆抗体。CD19在CAR-T细胞治疗领域被广泛应用，研究表明它是治疗B细胞急性淋巴细胞白血病（B-ALL）、慢性淋巴细胞白血病（CLL）和B细胞淋巴瘤等肿瘤的有效靶点，且安全性高。FMC63抗体的使用提升了CAR-T细胞治疗的精确性和安全性。

三、相关产品

Anti-FMC63scFv Monoclonal Antibody (SAA1996) (RAD10801)
Anti-Human CD19scFv Antibody (FMC63) (RHD10803)
Anti-FMC63scFv Monoclonal Antibody (SAA2162) (RAD10803)
Anti-Human CD19 Antibody (FMC63) (FHD10840)

四、产品详情

人生就是博-尊龙凯时的Anti-FMC63scFv Monoclonal Antibody (SAA1996) (RAD10801)

别名：FMC63，B-淋巴细胞抗原CD19，B-淋巴细胞表面抗原B4，分化抗原CD19，T细胞表面抗原Leu-12
货号：RAD10801
宿主：Rabbit
同种型：IgG
克隆类型：Monoclonal
靶标：Anti-human CD19 antibody clone FMC63, Idiotypic antibody
浓度：0.43 mg/ml
内毒素水平：请联系实验室获取信息
纯度：95%（由SDS-PAGE确定）
纯化方式：Protein A/G纯化自细胞培养上清
Accession号：P15391
克隆号：SAA1996
应用：ELISA
状态：液体
保存溶液：0.01M PB，pH 7.4
稳定性和存储条件：
- 短期（1-2周）：存放于4°C
- 长期（12个月）：存放于-20°C
- 长时间：存放于-80°C

五、参考文献

Solving the mystery of the FMC63-CD19 affinity PMID: 38155191
CD19 CAR antigen engagement mechanisms and affinity tuning PMID: 36867678
Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma PMID: 31959992
Identification of Potent CD19 scFv for CAR T Cells through scFv Screening with NK/T-Cell Line PMID: 33271901
Long-Term Follow-Up of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy PMID: 33021872
An novel CD19/CD22/CD3 trispecific antibody enhances therapeutic efficacy and overcomes immune escape against B-ALL PMID: 35981465
Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR PMID: 31477906
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study PMID: 38066564
Efficacy and safety of CD19 CAR T constructed with a new anti-CD19 chimeric antigen receptor in relapsed or refractory acute lymphoblastic leukemia PMID: 32894185
Activation priming and cytokine polyfunctionality modulate the enhanced functionality of low-affinity CD19 CAR T cells PMID: 36453632
Clinical Impact of Single Nucleotide Polymorphism in CD-19 on Treatment Outcome in FMC63-CAR-T Cell Therapy PMID: 37297020
T cells engineered with a novel VHH-based chimeric antigen receptor against CD19 exhibit comparable tumoricidal efficacy to their FMC63-based counterparts PMID: 36875091
Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation PMID: 35222427
Development and functional characterization of novel fully human anti-CD19 chimeric antigen receptors for T-cell therapy PMID: 33432627
Fully human CD19-specific chimeric antigen receptors for T-cell therapy PMID: 28202953
Stealth transgenes enable CAR T cells to evade host immune responses PMID: 38724463
Preparation and characterization of a chimeric CD19 monoclonal antibody PMID: 1725979
Point mutation in CD19 facilitates immune escape of B cell lymphoma from CAR T cell therapy PMID: 33023981
Directed evolution-based discovery of ligands for in vivo restimulation of CAR T cells PMID: 38659938
CD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia PMID: 38475814
Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity PMID: 18676854
CAR T cells outperform CAR NK cells in CAR-mediated effector functions in head-to-head comparison PMID: 38745250
Construction and characterization of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukemia and lymphoma PMID: 9566763
Immunotherapy of B cell lymphoma with CD22-redirected CAR NK-92 cells PMID: 37206593
Selective B cell depletion upon intravenous infusion of replication-incompetent anti-CD19 CAR lentivirus PMID: 35755944
Fine Epitope Mapping of the CD19 Extracellular Domain Promotes Design PMID: 31702909
Robust Antitumor Activity and Low Cytokine Production by Novel Humanized Anti-CD19 CAR T Cells PMID: 33632869
Development of a Novel Anti-CD19 CAR Containing a Fully Human scFv and Three Costimulatory Domains PMID: 35117999
Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR T Cell Patients PMID: 33843201
A durable 4-1BB-based CD19 CAR T cell for treatment of relapsed or refractory non-Hodgkin lymphoma PMID: 35355931

人生就是博-尊龙凯时旗下的武汉佰乐博生物技术有限公司为法国Antibodysystem品牌在亚洲区的授权总代理，提供近三万种蛋白、抗体等核心生命科学试剂，旨在为生命科学科研工作者提供专业、全面、可靠的试剂产品。